Research Progress on the Pharmacological Effects of Mogroside

Abstract

Background:
Mogroside, a natural sweetener from Siraitia grosvenorii (monk fruit), has gained attention for its pharmacological potential across multiple health conditions.

Objective:
To review the pharmacological effects, mechanisms of action, and therapeutic prospects of mogroside, with emphasis on its anti-diabetic, antioxidant, anti-inflammatory, and anti-cancer properties.

Methods:
This review collates and analyzes experimental and clinical studies focused on mogroside's biological activities and pharmacokinetics.

Results:
Mogroside demonstrates strong anti-diabetic properties via AMPK activation, enhances antioxidant enzyme levels, suppresses inflammation through NF-κB inhibition, and exhibits anticancer effects by modulating apoptosis and cell cycle pathways. It also shows promise in neuroprotection, cardioprotection, and immunomodulation. Challenges include limited bioavailability and incomplete understanding of mechanisms.

Conclusion:
Mogroside offers significant therapeutic potential. Future research should address clinical validation, delivery systems, and bioavailability enhancements to fully utilize its pharmacological benefits.