Nur77/NR4A1 Regulates Lung Macrophage Polarization in Repairing LPS-Induced Lung Damage in Acute Respiratory Distress Syndrome

Authors

  • Li Jun MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia & Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China.
  • Yulan Huang Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China
  • Chai Theam Ooi MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia
  • Jiang Yujie Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China
  • Barani Karikalan MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia

Keywords:

Nur77, NR4A1, Macrophages, Macrophage Polarization, Acute Respiratory Distress Syndrome

Abstract

Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition with severe pulmonary inflammation and high mortality.
Objective: Investigate Nur77/NR4A1's protective effect on macrophage polarization and lung repair in LPS-induced ARDS in mice.
Methods: 144 C57BL/6 mice divided into 4 groups. ARDS induced with LPS. CsnB used to activate Nur77. Lung injury assessed via histopathology, cytokine levels, and macrophage markers.
Results: CsnB reduced lung injury, promoted M2 macrophage polarization, reduced M1 markers, and accelerated tissue repair.
Conclusion: Nur77/NR4A1 regulates macrophage polarization and protects against inflammatory lung injury, offering a potential ARDS therapeutic target.

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Published

08-05-2025

How to Cite

Li Jun, Yulan Huang, Chai Theam Ooi, Jiang Yujie, & Barani Karikalan. (2025). Nur77/NR4A1 Regulates Lung Macrophage Polarization in Repairing LPS-Induced Lung Damage in Acute Respiratory Distress Syndrome. MAHSA International Journal of Health and Medicine (Mi-JHM), 5(1). Retrieved from http://journals.mahsa.edu.my/mijhm/article/view/25

Issue

Vol. 5 No. 1 (2025)

Section

Articles

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